| Dyslipidemia is a technical term used to describe medical disorders in blood lipid components. In everyday life we often hear the fat in the blood.
The treatment
The bile acid binding renins categories: drugs cholestyramine
(Questran), colestipol (colestid) ... not absorbed through the
intestines, it binds bile acids reduce their absorption.
Thus, the drug will increase the metabolism of cholesterol to bile
acids in the liver, reducing the amount of cholesterol in the liver
reserves and increases the activity of the receptor lipopotein low
density (LDL) of the liver. The drug reduced LDL-C by 30%, increase high density lipoprotein (HDL-C) for about 5% but increased slightly triglycerides. Therefore, often used in combination with other drugs and not as elevated triglyceride. Side effects may encounter include constipation, abdominal pain, nausea, vomiting, anxious ...
Nicotinic acid (niacin): This is a water soluble vitamin, inhibit hepatic production of lipoproteins. These drugs reduce LDL-C by 25% and increased HDL-C from 15-35%. Drug dose should start low, then the dose can be increased. Side effects: flushing skin feeling very common (found in almost all patients). It can be avoided by taking 100mg of aspirin meal or drink before each taking 30 minutes.
Other side effects include rash, nausea, vomiting ... Do not use this
medication for the patient group gout, peptic ulcer, chronic colitis. Patients with diabetes should use caution.
Inhibitors of HMG-CoA reductase inhibitors (statins): Includes
simvastatin (Zocor), lovastatin, pravastatin, fluvastatin, atorvastatin
(lipitor).
These drugs inhibit HMG-CoA enzyme activation reductase activity
reduces cholesterol synthesis in liver cells and increase LDL receptor
activation, thereby reducing LDL-C in the blood.
However, when taking the patient may experience: indigestion, diarrhea,
constipation, nausea, abdominal pain, headache, insomnia.
Do not take statins for patients with liver disease is progressing,
muscle pain, muscle inflammation ... NOTE: This medicine is liprobay
(cerivastatin) was withdrawn from the market due to side effects danger
of rhabdomyolysis when used with fibrat.
Fibrat derivatives (fibric acid): Includes gemfibrozil (Lopid),
clofibrat (lipavlon), fenofibrat (lipanthyl, Tricor), bezafibrat
(benzalip). Side effects may experience swelling of the face, abdominal pain, nausea, headache, rash ...
Replacement therapy with female hormones (estrogen): This method can be useful in postmenopausal women with dyslipidemia. Estrogen reduces LDL-C drink about 15% and increased HDL-C is about 15%. This should be the first choice drug for the treatment of postmenopausal women with dyslipidemia. However, this drug can increase triglyceride levels slightly. Can be used with progestin combination pill for women with dysmenorrhea.
Atherosclerosis by dyslipidemia
And combination drug problem
You can use two drugs in two different groups if necessary. The combination of the two drugs together with low-dose alternative to the use of a high dose so difficult to tolerate. In some cases, the increase in high blood cholesterol should combine the two drugs. The best combination is between statin and niacin.
Subscribe to medication
Need to check cholesterol and triglyceride blood every 3-4 weeks.
If no response after two months of treatment, although the optimal dose
should be replaced with another drug or drug combination Monday. Note that the adjustment of diet and exercise should always be guaranteed.
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